How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...
eLife: Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates
Mammalian cells dynamically scale translation initiation to match distinct elongation rates, preventing ribosome crowding and preserving protein synthesis homeostasis across diverse transcripts.